Problems of high-performance computer simulation and refining the technological regimes of forming airframe panels and calculation of their parts are considered. Some numerical results of using FEM-computations obtained on the MVS-1000 supercomputer and on a cluster of standard PCs are given. An algorithm designed for stress calculation with consideration of the material heteroresistance is applied. Simulation data are compared with small-scale and full-scale experiments. Computing efficiency of clusters with various number of nodes is estimated. This work was supported by the Russian Foundation for Basic Research (projects 07-01-00747, 06-II-СО-01-002, NS-9004.2006.1). The paper was prepared on the basis of the author’s report at the International Conference on Parallel Computing Technologies (PaVT-2007; http://agora.guru.ru/pavt2007).